Zotero Connector

alireza loghmani2024年10月17日

★★★★★5

Introduction Heatstroke is a life-threatening condition characterized by hyperthermia and systemic inflammation, leading to organ dysfunction. It results from prolonged exposure to high temperatures and can cause serious complications such as heat-induced inflammatory responses, oxidative stress, and tissue damage. While rapid cooling and supportive therapies are the standard treatment for heatstroke, the need for effective pharmacological interventions to mitigate inflammation and prevent organ failure remains critical. Exploring novel therapies targeting the inflammatory cascade in heatstroke has garnered considerable attention in recent years. Nanotechnology offers promising avenues for developing targeted therapeutic approaches in various medical conditions, including inflammatory diseases. Gold nanoparticles (GNPs) have emerged as a highly versatile and biocompatible nanocarrier due to their tunable size, surface functionality, and ability to deliver bioactive molecules directly to affected tissues. Recent studies have demonstrated the potential of GNPs in mitigating inflammation and oxidative stress in various pathological conditions. Among potential therapeutic agents, betaine—a naturally occurring compound with antioxidant and anti-inflammatory properties—has shown promise in reducing inflammatory responses and protecting against tissue damage. This study aims to investigate the anti-inflammatory effects of gold nanoparticle carriers conjugated with betaine in a mouse heatstroke model. By combining the unique properties of GNPs with the known therapeutic benefits of betaine, this research seeks to provide insights into the efficacy of nanoparticle-based interventions in mitigating heatstroke-induced inflammation and oxidative damage. Background Heatstroke and Inflammation Heatstroke occurs when the body's core temperature rises above 40°C (104°F), resulting in hyperthermia and systemic inflammation. The condition is associated with the excessive production of pro-inflammatory cytokines, such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), which contribute to cellular damage and organ dysfunction. Studies have shown that oxidative stress plays a significant role in amplifying the inflammatory response during heatstroke, leading to increased cell death and tissue injury in organs such as the liver, kidneys, and brain.

fab v2024年10月16日

★★★★★4

Bonjour, Vous pouvez trouver sur you tube un tuto et pour l'insérer sur word, il faut installer le plugins dont voici le lien https://www.zotero.org/support/plugins.

张梦璇2024年10月16日

★★★★★3

突然用不了了，提示：使用 APA PsycNet 保存时发生错误。改为尝试用 Save as Webpage 保存

John Tsiamantas2024年10月15日

★★★★★5

Best Citation Manager by far!

Julia K2024年10月11日

★★★★★5

I use it daily in my studies in either Google Chrome or Opera (that needs an extension that allows Google extensions).

Wanda Criswell2024年10月4日

★★★★★1

Zotero is really difficult to use, the UI is very complicated and not at all intuitive.

Jessika Dethlefs Canto2024年10月2日

★★★★★1

Antes la sincronización funcionava perfecto y de un dia para otro no sincroniza con word

Emma bedu2024年10月2日

★★★★★3

Bonjour, l'appli fonctionne, en revanche je n'arrive pas à insérer une bibliographie dans un document word. Quelqu'un pourrait-il m'aider?

Marcelo Scalona2024年9月29日

★★★★★3

Necesito ayuda. no puedo sincronizar zotero con word, cuando abro editar no me aparece preferencias.

Anass Adenane2024年9月24日

★★★★★5

J'ADORE CETTE EXTENSION, ICI CA BIBLIOGRAPHIE, ICI CA BIBLIOGRPAHIE PAS MAL, J'ADORE, A BON ENTENTENDEUR, BISOUS A VOUS ET JE M'ANVOLE